Track topics on Twitter Track topics that are important to you
Oxotryptamines were firstly used as flexible four-atom synthons in an NHC-catalyzed formal [4+3] annulation, providing a novel enantioselective method to access structurally diverse spiro-ε-lactam oxindoles with excellent enantioselectivities. This metal-free reaction features a broad substrate scope, excellent functional-group tolerance and proceeds under mild reaction conditions. Importantly, enantiopure privileged hexahydropyrroloindoles could be easily constructed via an one-pot process from the resulting spiro-ε-Lactam oxindoles.
This article was published in the following journal.
Name: Chemistry (Weinheim an der Bergstrasse, Germany)
Lewis acid catalyzed highly efficient [3+2] annulation of spirocyclic Donor-Acceptor cyclopropanes (DACs) with exo-heterocyclic olefins is reported to furnish various biologically relevant dispiro-2,3...
The N-heterocyclic carbene-catalyzed synthesis of 2,2'-dihydroxybenzophenones from ß-methylenals and aurones was developed. The cleavage of C-O bond via retro-Michael addition is the key step from th...
Diverse spiro dihydroquinoline-oxindoles (JS series) were prepared using the BF•OEt-catalyzed imino Diels-Alder reaction between ketimine-isatin derivatives and trans-isoeugenol. Ten spiro-oxiindole...
In contrast to well-established asymmetric hydrogenation reactions, enantioselective protonation is an orthogonal approach to create highly valuable methine chiral centers under redox-neutral conditio...
N-Heterocyclic carbene(NHC)-stabilized copper nanoparticles are synthesized using a NHC-borane and mesitylcopper(I) in thermal conditions (refluxing toluene for 2.5 h). Nanoparticles (NPs) with a size...
This 3 arm study will compare the efficacy and safety of beta-lactam with that of 'standard care' in patients with complicated skin and skin structure infections requiring hospitalization....
Problematic: Spirometry is used to objectify the obstructive syndrome defining chronic obstructive pulmonary disease (COPD). However, this test remains underused in the primary care. The t...
This study will assess the efficacy and safety of intravenous beta-lactam, in comparison with ceftriaxone, in hospitalized patients with community-acquired pneumonia not caused by Legionel...
The purpose of this study is to determine whether a monotherapy with a Beta-Lactam is not inferior to an association of a Beta-Lactam and a macrolide in treating adult patients with commun...
GCX damage and its relationship to pharmacodynamics and pharmacokinetics of beta lactam antibiotics in critically ill Hypothesis to be tested: GCX damage impairs pharmacodynamics and pharm...
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
Heterocyclic compounds that contain two rings that share two non-adjacent atoms in common.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Multiple ring heterocyclic compounds containing two or more rings that share two atoms and one bond in common.