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Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: a case series.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Reflectance confocal microscopy may enhance the accuracy of histopathologic diagnosis: a case series."

Although histopathology is the time-honored gold standard diagnostic measure in dermatology, several factors may detract from an accurate microscopic diagnosis. Limiting factors include: human error, suboptimal biopsy-site selection or biopsy technique, and inherent restrictions of vertical tissue sectioning that lead to incomplete microscopic evaluation of the lesion. Reflectance confocal microscopy (RCM) is a non-invasive imaging tool that allows for the cellular-level examination of the lesion, at a horizontal plane, which may complement the subsequent vertical histopathological tissue examination. Herein, we report a case series whereby pre-biopsy RCM examination enhanced the accuracy of histopathological diagnosis or allowed for a critical appraisal of initial histopathological misdiagnosis. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of cutaneous pathology
ISSN: 1600-0560
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Medical and Biotech [MESH] Definitions

Fluorescence microscopy utilizing multiple low-energy photons to produce the excitation event of the fluorophore. Multiphoton microscopes have a simplified optical path in the emission side due to the lack of an emission pinhole, which is necessary with normal confocal microscopes. Ultimately this allows spatial isolation of the excitation event, enabling deeper imaging into optically thick tissue, while restricting photobleaching and phototoxicity to the area being imaged.

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