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We read with interest the very valuable article recently published by Na and colleagues  that deciphered the crucial role of focal adhesion kinase (FAK)/β-catenin (CAT) network in hepatocarcinogenesis. In order to unveil this mechanism the authors overexpressed FAK alone, constitutively active CAT alone, or a combination of both in the livers of C57/BL6 mice. FAK overexpression or CAT mutation were not sufficient to induce HCC, whereas combined FAK/CAT led to hepatocarcinogenesis in mouse. Na et al.  also demonstrated that FAK activity was crucial for development of FAK/CAT-dependent HCC. The authors found that many genes closely related to hepatocarcinogenesis were enriched in FAK/CAT-induced HCCs, including genes involved in oxidative phosphorylation, fatty acid metabolism, adipogenesis, mechanistic target of rapamycin complex 1 signaling, G2/M checkpoint, mitotic spindle formation, and cholesterol homeostasis. Interestingly, in the liver samples of FAK/CAT mice the authors revealed a significant increase of the CAT binding to the promoter of androgen receptor (AR) respect to the control samples. AR has been previously reported as a direct transcriptional target of CAT/transcription factor 4 . This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Hepatology (Baltimore, Md.)
A novel control strategy for synchronization control for network systems with communication constraints is presented in this paper. The dynamics of nodes in the network are nonidentical. The communica...
Various epigenetic modifications, including histone lysine methylation, play an integral role in learning and memory. The importance of the histone lysine methyltransferase complex G9a/GLP and its ass...
We study the optimal interventions of a regulator (a central bank or government) on the illiquidity default contagion process in a large, heterogeneous, unsecured interbank lending market. The regulat...
In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being o...
In the last decade, epigenetics has taken center stage to explain the relationships between stress exposure, health and behavior. Acquired or inherited epigenetic changes modulate gene expression stat...
The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process. DNA is the primary genetic material, ...
The prevalence of obesity is increasing and affects more than 650 million people of all ages to become one of the foremost global health threats. Obesity is a complex syndrome that can ser...
Expression of Erythroid differentiation regulator 1 (Erdr1) cytokine in vitiligo
Relapse is the most serious problem in alcoholism treatment. The overall aim of the present study was to determine if a treatment directed at changing the patient's social network, from on...
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
A DNA binding protein, transcriptional regulator, and proto-oncogene protein that contains 10 CYS2-HIS2 ZINC FINGERS. It functions as a positive or negative regulator of expression for target genes involved in organism development.
A cyclin subtype that binds to the CYCLIN-DEPENDENT KINASE 3 and CYCLIN-DEPENDENT KINASE 8. Cyclin C plays a dual role as a transcriptional regulator and a G1 phase CELL CYCLE regulator.
An adaptor protein complex involved in transport of molecules between the TRANS-GOLGI NETWORK and the endosomal-lysosomal system.
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
The development and maintenance of an organism is orchestrated by a set of chemical reactions that switch parts of the genome off and on at strategic times and locations. Epigenetics is the study of these reactions and the factors that influence them. ...
Statins (or HMG-CoA reductase inhibitors) are a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Increased cholesterol levels have been as...