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Treatment of allergic disease with nanoemulsion adjuvant vaccines.

08:00 EDT 12th July 2019 | BioPortfolio

Summary of "Treatment of allergic disease with nanoemulsion adjuvant vaccines."

The majority of allergic diseases, including asthma, atopic dermatitis and food allergy, are caused by allergen-specific IgE production and Th2-polarized immune responses. Allergic sensitization is caused by DC activation of naïve T cells to generate and expand Th2-biased cellular immune responses, resulting in the production of cytokines such as IL-4, IL-5 and IL-13. Th2 cytokines induce the generation and expansion of allergen-specific IgE by B cells as well as accumulation of mast cells in tissues (Figure 1). Because of the central role Th2 immune responses play in the genesis of allergic disease, it is important to focus on therapeutic approaches capable of suppressing or redirecting these Th2 immune responses. This article is protected by copyright. All rights reserved.

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Name: Allergy
ISSN: 1398-9995
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