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The majority of allergic diseases, including asthma, atopic dermatitis and food allergy, are caused by allergen-specific IgE production and Th2-polarized immune responses. Allergic sensitization is caused by DC activation of naïve T cells to generate and expand Th2-biased cellular immune responses, resulting in the production of cytokines such as IL-4, IL-5 and IL-13. Th2 cytokines induce the generation and expansion of allergen-specific IgE by B cells as well as accumulation of mast cells in tissues (Figure 1). Because of the central role Th2 immune responses play in the genesis of allergic disease, it is important to focus on therapeutic approaches capable of suppressing or redirecting these Th2 immune responses. This article is protected by copyright. All rights reserved.
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Several European countries have observed an association between narcolepsy and H1N1 vaccines containing AS03 adjuvant in children/adolescents. In Taiwan, a nationwide campaign starting November 2009 a...
The present work formed lutein-enriched nanoemulsions stabilized by sodium caseinate (SC) using a high-pressure homogenization process, and the influence of environmental conditions on the physicochem...
Adjuvants are a critical component for vaccines, especially for a poorly-immunogenic antigen, such as nicotine. However, the impact of adjuvant release rate from a vaccine formulation on its immunogen...
Allergic asthma often coexists with different pathological conditions, called multimorbidities, that are mostly of allergic nature and share a common underlying inflammatory pathophysiological mechani...
Allergic patients have life-long chronic inflammatory diseases with repeated relapses and exacerbations. Currently used allergy therapeutics have some limitations, which warrants a search for novel dr...
This study evaluates the use of Brimonidine tartrate nanoemulsion eye drop solution in the treatment of Dry Eye Disease (DED). Half of participants will receive Brimonidine and half will r...
This study evaluates the use of Brimonidine tartrate nanoemulsion eye drop solution in the treatment of ocular Graft Verses Host Disease (oGVHD). Two thirds of participants will receive Br...
This study investigates the efficacy of photodynamic therapy (PDT) in the treatment of lentigo maligna (LM). Hyperspectral imaging system (HIS) will be used to determine the margins of LM ...
The purpose of this study is to test three experimental HIV vaccines. This study will look at whether it is safe to give these vaccines together and how the immune system responds to the ...
The purpose of the research is to determine which inflammatory substances are involved in causing allergic symptoms in the eye. Allergic conjunctivitis is a common problem with symptoms of...
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Vaccines or candidate vaccines used to prevent MAREK DISEASE, an avian disease caused by a herpesvirus.
Vaccines or candidate vaccines used to prevent LYME DISEASE.
Vaccines or candidate vaccines used to prevent PSEUDORABIES (Aujeszky's disease), a herpesvirus of swine and other animals.
The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...
Eczema is a common itchy skin disease characterized by reddening and vesicle formation, which may lead to weeping and crusting. It is endogenous, or constitutional. There are five main types; atopic, seborrhoeic, discoid, gravitational or varicose. ...
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...