Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus.

08:00 EDT 16th July 2019 | BioPortfolio

Summary of "Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus."

Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals.


Journal Details

This article was published in the following journal.

Name: Acta physiologica (Oxford, England)
ISSN: 1748-1716
Pages: e13345


DeepDyve research library

PubMed Articles [5666 Associated PubMed Articles listed on BioPortfolio]

Auto-Regulation of Leptin Neurobiology.

The clinical use of the hormone leptin, a key regulator of food intake, to treat the most common instances of obesity has so far failed. In this issue, Zhao et al. (2019) report that, paradoxically, ...

Leptin rs7799039 polymorphism is associated with multiple sclerosis risk in Kuwait.

Leptin association with Multiple sclerosis (MS) pathogenesis and MS related clinical characteristics is inconsistent. Here, we investigated whether two common variants in leptin (LEP) and leptin recep...

Maternal serum and cord blood leptin concentrations at delivery.

Studies have demonstrated leptin involvement in the physiology and pathophysiology of pregnancy and suggest that leptin may be a prognostic marker for some complications of pregnancy although the asso...

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.

The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The tyrosine phosphatases protein tyrosine phosphatase 1B (PTP1B) and T cel...

'Fat's chances': Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus.

Leptin, a critical mediator of feeding, metabolism and diabetes, is expressed on an incidental basis according to satiety. The genetic regulation of leptin should similarly be episodic.

Clinical Trials [2427 Associated Clinical Trials listed on BioPortfolio]

Impact of Exercise on the Metabolic Consequences of Overeating

The primary purpose of this study is to examine the effects of 1-week of overeating on important clinical metabolic health outcomes (e.g., glucose tolerance, blood lipid profile, and blood...

Ketogenic Diet for Obesity Hypoventilation Syndrome

Obesity hypoventilation syndrome (OHS) causes hypercapnia (PaCO2>45) in subjects with obesity in the absence of lung disease, and is associated with respiratory failure, pulmonary hyperten...

Effects of Leptin Replacement in Children

We will assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous Turkish family. We hypothesize that leptin replacement will have ...

The Effects of Metreleptin in Congenital Leptin Deficiency

This study has been designed to 1) provide access to metreleptin to the only two individuals in the US known to have congenital leptin deficiency (CLD) and 2) explore a variety of unanswer...

Low-Dose Leptin and the Formerly-Obese

Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the circu...

Medical and Biotech [MESH] Definitions

Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Compounds that bind to and inhibit the action of 5-LIPOXYGENASE-ACTIVATING PROTEINS.

A family of gram-negative bacteria in the order Nitrosomonadales. It formerly included the genera CAMPYLOBACTER and SPIRILLUM, then was abandoned, and is now reinstated as a family with a single genus SPIRILLUM.

An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.

Quick Search

DeepDyve research library

Relevant Topic

Endocrine Disorders
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...

Searches Linking to this Article