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Ligand Controlled Ir-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes.

08:00 EDT 16th July 2019 | BioPortfolio

Summary of "Ligand Controlled Ir-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes."

An intramolecular Ir(III)-catalyzed regiodivergent oxyamination of unactivated alkenes provides valuable γ-lactams, γ-lactones and δ-lactams. The regioselectivity is controlled by the electronically tunable cyclopentadienyl Ir(III)-complexes enabling oxyamination via either 5-exo or 6-endo pathways. With respect to the mechanism, we propose a highly reactive [3.1.0] bicycle intermediate derived from Ir(V) nitrene-mediated aziridination to be a key intermediate toward the synthesis of γ-lactams.

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This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126
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