The Effect of Subinhibitory Concentrations of -Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Strains.
Summary of "The Effect of Subinhibitory Concentrations of -Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Strains."
The aim of this study was to evaluate the effect of subinhibitory concentrations of -anethole on antibacterial and antibiofilm properties of mupirocin against mupirocin-resistant strains. Following parameters were examined: isolates susceptibility to antibiotics, minimum inhibitory concentration (MIC) of -anethole, antibacterial activity of mupirocin/-anethole combination, detection of gene, genotypic relativity of isolates using pulsed-field gel electrophoresis method, and the influence of mupirocin/-anethole combination on biofilm formation. Our study revealed that -anethole combined with mupirocin increased the growth inhibition zone diameter around the mupirocin disk, independently on strains susceptibility to this antibiotic. Moreover, combination of subinhibitory (MIC) concentration of mupirocin and -anethole significantly decreased biofilm biomass. Anethole appeared efficient in increasing susceptibility to mupirocin and decreasing biofilm formation in strains used in this study. Reduction of biofilm formation can potentially protect against recolonization. Moreover, use of anethole in combination with mupirocin can increase the mupirocin activity against methicillin-resistant and mupirocin-resistant strains.
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Journal Details
This article was published in the following journal.
Name: Microbial drug resistance (Larchmont, N.Y.)
ISSN: 1931-8448
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31314694
- DOI: http://dx.doi.org/10.1089/mdr.2019.0101
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Medical and Biotech [MESH] Definitions
Dibromothymoquinone
At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity.
Mupirocin
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Blood Bactericidal Activity
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
Placebo Effect
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Nitrous Oxide
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
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