Untargeted metabolomics of the bacterial tongue coating of intra-oral halitosis patients.

08:00 EDT 18th July 2019 | BioPortfolio

Summary of "Untargeted metabolomics of the bacterial tongue coating of intra-oral halitosis patients."

Intra-oral halitosis (IOH) refers to an unpleasant odour from the oral cavity that is mainly caused by the tongue coating. Although the tongue coating microbiome is thought to play an essential role in IOH, the exact aetiology of IOH remains unclear. Here we investigated and compared the metabolic profiles of the tongue coating microbiomes of patients with IOH versus healthy control. The metabolic profiles were significantly different in IOH patients than in healthy controls. Healthy controls showed higher selenoamino acid and nicotinamide metabolism; these metabolic pathways are mainly involved in maintaining the oxidation-reduction potential and redox state. A total of 39 putative metabolites were associated with IOH. Remarkably, 3 of the metabolites, branched-chain fatty acids (BCFA), 3-fumaryl pyruvate, and acetyl phosphate, are potential key players in IOH. Interestingly, the predominant metabolite in IOH is BCFAs, which might underlie tongue coat formation. In addition, the key metabolite acetyl phosphate has a clear association with the hydrogen sulfide- (H2S-) producing metabolic pathway and anaerobic fermentation. These novel metabolomic findings provide insights into the formation of the tongue coating and the production of H2S, which causes bad breath.
 Keywords: Intra-oral halitosis, Tongue coating, Microbiome, Metabolites, Hydrogen sulfide (H2S)&#13.


Journal Details

This article was published in the following journal.

Name: Journal of breath research
ISSN: 1752-7163


DeepDyve research library

PubMed Articles [10383 Associated PubMed Articles listed on BioPortfolio]

A simple method to reduce halitosis; tongue scraping with probiotics.

We aimed to assess the effects of probiotic implantation to the dorsum of the tongue against halitosis.

Relationship of tongue coating microbiome on volatile sulfur compounds in healthy and halitosis adults.

This study aims to assess the microbiome variations related to intraoral halitosis and its relationship with volatile sulfur compounds (VSCs) among periodontally healthy Chinese adults.

New insights into pediatric community-acquired pneumonia gained from untargeted metabolomics: A preliminary study.

Available diagnostics often fail to distinguish viral from bacterial causes of pediatric community-acquired pneumonia (pCAP). Metabolomics, which aims at characterizing diseases based on their metabol...

Pathway Analysis for Targeted and Untargeted Metabolomics.

Recent advances in analytical techniques, particularly LC-MS, generate increasingly large and complex metabolomics datasets. Pathway analysis tools help place the experimental observations into releva...

A Study of 31 Patients with Primary Complaint of Halitosis in a Tertiary Hospital in South-Western Nigeria.

Halitosis is a common cause of dental consulta-tion. Patients presenting with primary complaint of halitosis consist of dissatisfied people with genuine and pseudo-halitosis.

Clinical Trials [7616 Associated Clinical Trials listed on BioPortfolio]

Inulin and S. Salivarius Reduce Halitosis

Halitosis associated with tongue coating results from the production of volatile sulfur compounds by bacterial action. The use of prebiotics and probiotics might be useful in treating such...

Evaluation of Halitosis After Treatment With Photodynamic Therapy Associated With Periodontal Treatment

The aim of this randomized, controlled clinical trial was to treat oral halitosis in healthy adults with photodynamic therapy associated with periodontal treatment and follow them up for 3...

Evaluation of Halitosis After Treatment With Photodynamic Therapy

Halitosis is the term used to define an unpleasant odor emanating from the mouth. Some lung diseases, such as bronchiectasis, are among the extra-oral causes of this condition. However, no...

Laser Tongue Debridement for Oral Malodor

Malodor is a multifactorial condition with oral pathology representing the main culprit and the tongue being the first to second contributor to the malodor. Bacterial load can represent a ...

Comparative Study Between Photodynamic Therapy With Urucum and LED and Probiotics in Halitosis Reduction

Halitosis is a term that defines any odor or bad smell from the oral cavity, which may have local or systemic origin. This project aims to verify whether the treatment with antimicrobial p...

Medical and Biotech [MESH] Definitions

An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.

A severe congenital restriction of TONGUE movement, resulting from fusion or adherence of the tongue to the floor of the mouth. In partial ankyloglossia (tongue-tie) the LINGUAL FRENUM is abnormally short, or is attached too close to the tip of the tongue. OMIM: 106280

A method of treating an ALLERGY by administering ALLERGENS, in liquid formulation or tablets, to the ORAL MUCOSA under the tongue.

Tuberculosis of the mouth, tongue, and salivary glands.

A benign condition of the tongue characterized by hypertrophy of the filiform papillae that give the dorsum of the tongue a furry appearance. The color of the elongated papillae varies from yellowish white to brown or black, depending upon staining by substances such as tobacco, food, or drugs. (Dorland, 27th ed)

Quick Search

DeepDyve research library

Relevant Topics

Dentistry is the study, management and treatment of diseases and conditions affecting the mouth, jaw, teeth and their supporting tissues (Oxford Medical Dictionary) The work of a dentist ranges from regular patient check-up to orthodontics and surgery....

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Asthma COPD Cystic Fibrosis Pneumonia Pulmonary Medicine Respiratory Respiratory tract infections (RTIs) are any infection of the sinuses, throat, airways or lungs.  They're usually caused by viruses, but they can also ...

Searches Linking to this Article