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Depression is considered as a maladaptive response to stress in adult life. Exposure to stress in early childhood is recognized as a risk factor for being unable to adapt to environmental changes in adult life. Early life stress (ELS) has been modelled in animals to help understand the behavioral outcome of the adversity. Periodic maternal separation (MS) in rodents for the first two weeks of life is one such model. We used MS as a form of ELS in Balb/c mice to study its effect on a stressful challenge encountered in adult life. According to our results, exposure to MS predisposed mice to an altered behavioral response. However, this response was not worsened by exposure to restraint stress (RS) experienced in early adult life. This controversy may be attributed to methodological and biological variations among animals as well as humans.
This article was published in the following journal.
Name: Physiology & behavior
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The human ability to adapt in the face of tragedy, trauma, adversity, hardship, and ongoing significant life stressors.
An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS.
An early growth response transcription factor that is essential for the development of MUSCLE SPINDLES.
Action taken to reduce susceptibility or exposure to health problems and to detect and treat disease in early stages.
Behavioral response associated with the achieving of gratification.
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