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Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects.

08:00 EDT 19th July 2019 | BioPortfolio

Summary of "Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects."

Ruxolitinib is metabolized by cytochrome P450 (CYP)3A4 and CYP2C9. Dual inhibitors of these enzymes (like fluconazole) lead to increased ruxolitinib exposure relative to a single pathway inhibition of CYP3A4 or CYP2C9. The magnitude of this interaction, previously assessed via physiologically based pharmacokinetic (PBPK) models, was confirmed in an open-label, phase 1 study in healthy subjects.

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Name: Cancer chemotherapy and pharmacology
ISSN: 1432-0843
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