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Targeted molecular characterization shows differences between primary and secondary myelofibrosis.

08:00 EDT 24th July 2019 | BioPortfolio

Summary of "Targeted molecular characterization shows differences between primary and secondary myelofibrosis."

In BCR-ABL1-negative myeloproliferative neoplasms, myelofibrosis (MF) is either primary (PMF) or secondary (SMF) to polycythemia vera or essential thrombocythemia. MF is characterized by an increased risk of transformation to acute myeloid leukemia (AML) and a shortened life expectancy.

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This article was published in the following journal.

Name: Genes, chromosomes & cancer
ISSN: 1098-2264
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Medical and Biotech [MESH] Definitions

A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.

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