Synthesis of the Madangamine Alkaloid Core by a C-C Bond Activation Cascade.

08:00 EDT 24th July 2019 | BioPortfolio

Summary of "Synthesis of the Madangamine Alkaloid Core by a C-C Bond Activation Cascade."

The diazatricyclic core of the madangamine alkaloids was synthesized from a densely functionalized cyclohexane derivative. An alkene and two cyanoformamide groups are used to form two new rings and a new quaternary stereocenter in a cascade reaction, which involves two Pd-catalyzed C-C bond activation steps. The synthesis of the cascade precursor involves an intramolecular Staudinger reaction of a vicinal diester that gives a [3.2.1]azabicyclooctane derivative, allowing the regioselective introduction of a monosubstituted alkene.


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Name: Organic letters
ISSN: 1523-7052


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