Adult T cell lymphoblastic leukemia/lymphoma by HTLV-1 in a young woman.

08:00 EDT 1st April 2019 | BioPortfolio

Summary of "Adult T cell lymphoblastic leukemia/lymphoma by HTLV-1 in a young woman."

Adult T cell lymphocyte leukemia/lymphoma (ATLL) is a subtype of T-cell lymphoma caused by infection of the human T-cell lymphotropic virus type 1 (HTLV-1); which generates a pro-viral integration into the host DNA, resulting in a clonal expansion of T lymphocytes. We present the case of a 20-year-old woman who developed multiple lymphadenopathies, hepatosplenomegaly and fever, serum positivity for HTLV-1 and proviral integration in the host DNA, demonstrated by polymerase chain reaction (PCR). Immunohistochemistry of lymphoid node was positive to CD4+ and CD8+ T cells. ATLL has been described in all HTLV-1 endemic areas, however, there are differences in the mean age of its presentation in such areas: 40 to 50 years in South America, 60 years in Japan. We showed one of few reported cases of the lymphoma type of ATLL in young adults.


Journal Details

This article was published in the following journal.

Name: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia
ISSN: 0717-6341
Pages: 234-237


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