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Adalimumab- Induced Scalp Psoriasis with Severe Alopecia.

08:00 EDT 26th July 2019 | BioPortfolio

Summary of "Adalimumab- Induced Scalp Psoriasis with Severe Alopecia."

In recent years, with the increase usage of tumour necrosis factor (TNF) inhibitors, more side effects have revealed. The incidence of paradoxical psoriasis (psoriasis vulgaris, palmoplantar pustulosis, scalp psoriasis or their combinations) ranges from 1 to 5%; however alopecia due to anti-TNF- α-induced scalp psoriasis, rarely reported in the literature. We report a 37-year-old woman who developed palmoplantar pustulosis and scalp psoriasis with severe alopeciaafter 2 months of treatment with adalimumab for chronic plaque psoriasis. Biopsies from the palmar and scalp lesions showed psoriasiform changes. Adalimumab treatment was discontinued, and methotrexate wasstarted (15 mg/weekly, subcutaneously) with topical adjuvant agents. A dramatic improvement was seen in both the skin and scalp with complete hair regrowth in one month. We conclude that, in anti-TNF-α-induced scalp psoriasis, suspension of anti-TNF- α agent and systemic and topical treatments should be considered in order to avoid scarring alopecia. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Dermatologic therapy
ISSN: 1529-8019
Pages: e13033

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