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Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss.

08:00 EDT 26th July 2019 | BioPortfolio

Summary of "Up-regulated HIF-2α contributes to the Osteoarthritis development through mediating the primary cilia loss."

Up-regulated HIF-2α (hypoxia induced factor 2) had been demonstrated to contribute to Osteoarthritis (OA) development via inducing the expression of matrix-degrading enzymes. However, the HIF-2α also could promote primary cilia loss through HIF-2α/AURKA (Aurora kinase A)/NEDD9 pathway. And the primary cilia dysfunction is another characteristic of the OA. Thus, we investigated here whether the HIF-2α also contributes the OA development through mediating the primary cilia loss.

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This article was published in the following journal.

Name: International immunopharmacology
ISSN: 1878-1705
Pages: 105762

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Medical and Biotech [MESH] Definitions

A consistent pattern of food and drink consumption that contributes to the development and advancement of DENTAL CARIES.

A diet that contributes to the development and acceleration of ATHEROGENESIS.

A class of ciliate protozoa. Characteristics include the presence of a well developed oral apparatus and oral cilia being clearly distinct from somatic cilia.

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Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)

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