Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges.

08:00 EDT 31st July 2019 | BioPortfolio

Summary of "Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges."

Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the near infrared. Despite high molar absorptivities and fluorescence quantum yields, these dyes have been less explored than other dye scaffolds due to their susceptibility to nucleophilic attack. Recent strategies in probe design including encapsulation, conjugation to biomolecules, and new synthetic modifications have seen squaraine dyes emerging into the forefront of biomedical imaging and other applications. Herein, we provide a concise overview of 1) the synthesis of symmetrical and unsymmetrical squaraine dyes; 2) the relationship between structure and photophysical properties of squarine dyes; 3) current applications of squaraine dyes in the literature. Given the recent successes at overcoming the limitations of squaraine dyes, they show a high potential in biological imaging, photodynamic and photothermal therapies, and as molecular sensors.


Journal Details

This article was published in the following journal.

Name: Bioconjugate chemistry
ISSN: 1520-4812


DeepDyve research library

PubMed Articles [20941 Associated PubMed Articles listed on BioPortfolio]

Molecular Design, Synthetic Strategies, and Applications of Cationic Polythiophenes.

This review delves into the synthesis of cationic-functionalized oligothiophenes and polythiophenes, their properties, and their diverse applications from the year 2002 to 2019. Pristine polythiophene...

Fluorescent hybrid silica nanoparticles and their biomedical applications.

Benefitting from the subtle combination of robust inorganic silica with organic dyes, fluorescent hybrid silica nanoparticles are getting more and more attention by virtue of their excellent aqueous s...

Binary (Split) Light-up Aptameric Sensors.

This review discusses the design and applications of binary (also known as split) light-up aptameric sensors (BLAS). BLAS consist of two RNA or DNA strands and an fluorogenic organic dye added as a bu...

Photoinduced H-aggregation of cationic dyes on metal-oxide surfaces via light activated molecular migration.

Molecular transport by use of light energy is a new photofunction for light powered molecular carriers and light induced nano-structure formation on a substrate. However, this research field has not b...

Tailoring Kidney Transport of Organic Dyes with Low Molecular-weight PEGylation.

Subtle changes in size can induce distinct responses of the body to hard nanomaterials; however, it is largely unknown whether just few ethylene oxide-unit differences in soft poly(ethylene glycol) (P...

Clinical Trials [4874 Associated Clinical Trials listed on BioPortfolio]

Study of the Effects of Photobiomodulation in Patients With Osteoarthritis

PhotoBioModulation (PBM) is a mature science with therapeutic efficacy in humans and animals, and with excellent results in different medical specialties without side effects. However ther...

Chromocolonoscopy With Food-grade Dyes

Previous with methylene blue suggested that oral administration may be superior to conventional spray catheters. The main advantages claimed were better staining due to longer exposure to ...

Effect of the Membrane Blue Dual® Dye on the Retinal Sensitivity in Macular Hole Surgery

The idiopathic macular hole, age-related disease, is a major cause of vision loss and affects at least two persons in 1000 after 40 years. This hole causes an acute decline linked to a ce...

Use of Smartphone Health Applications Among Patients Aged 18 to 69 Years Recruited in Primary Care in Grenoble Area

This study evaluates the frequency of use of smartphone health applications among people consulting in primary care in the Grenoble region, France. This is a descriptive study using a que...

Smartphone Application-Based Vital Sign Monitors

Health-related applications for smartphones represent a new and popular market for consumer oriented products. These applications are generally not considered medical devices and, as such,...

Medical and Biotech [MESH] Definitions

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.

An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Dyes used as cosmetics to change hair color either permanently or temporarily.

Quick Search

DeepDyve research library

Relevant Topic

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...

Searches Linking to this Article