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Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges.

08:00 EDT 31st July 2019 | BioPortfolio

Summary of "Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges."

Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the near infrared. Despite high molar absorptivities and fluorescence quantum yields, these dyes have been less explored than other dye scaffolds due to their susceptibility to nucleophilic attack. Recent strategies in probe design including encapsulation, conjugation to biomolecules, and new synthetic modifications have seen squaraine dyes emerging into the forefront of biomedical imaging and other applications. Herein, we provide a concise overview of 1) the synthesis of symmetrical and unsymmetrical squaraine dyes; 2) the relationship between structure and photophysical properties of squarine dyes; 3) current applications of squaraine dyes in the literature. Given the recent successes at overcoming the limitations of squaraine dyes, they show a high potential in biological imaging, photodynamic and photothermal therapies, and as molecular sensors.

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Name: Bioconjugate chemistry
ISSN: 1520-4812
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