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Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect.

08:00 EDT 19th July 2019 | BioPortfolio

Summary of "Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect."

Oxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer's disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.

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This article was published in the following journal.

Name: Journal of pharmacological sciences
ISSN: 1347-8648
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Medical and Biotech [MESH] Definitions

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