A Rh(III)-Catalyzed Formal 4+1 Approach to Pyrrolidines from Unactivated Terminal Alkenes and Nitrene Sources.

08:00 EDT 5th August 2019 | BioPortfolio

Summary of "A Rh(III)-Catalyzed Formal 4+1 Approach to Pyrrolidines from Unactivated Terminal Alkenes and Nitrene Sources."

We have developed a formal [4+1] approach to pyrrolidines from readily available unactivated terminal alkenes as 4-carbon partners. The reaction provides a rapid construction of various pyrrolidine containing structures, especially for the diastereoselective synthesis of spiro-pyrrolidines. Mechanistic investigation suggests a Rh(III)-catalyzed intermolecular aziridination of the alkene and subsequent acid-promoted ring expansion for the pyrrolidine formation.


Journal Details

This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126


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Alkenes with the general formula H2C=CH-CH2-R.

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