Dose Optimization of Valproic Acid in a Lethal Model of Traumatic Brain Injury, Hemorrhage and Polytrauma in Swine.

08:00 EDT 5th August 2019 | BioPortfolio

Summary of "Dose Optimization of Valproic Acid in a Lethal Model of Traumatic Brain Injury, Hemorrhage and Polytrauma in Swine."

Trauma is a leading cause of death, and traumatic brain injury (TBI) is one of the hallmark injuries of current military conflicts. VPA administration in high doses (300-400 mg/kg) improves survival in lethal trauma models, but effectiveness of lower doses on survival is unknown. This information is essential for properly designing the upcoming clinical trials. We, therefore, performed the current study to determine the lowest dose at which VPA administration improves survival in a model of lethal injuries.


Journal Details

This article was published in the following journal.

Name: The journal of trauma and acute care surgery
ISSN: 2163-0763


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