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Sulfated polysaccharides from Rhodiola sachalinensis reduce d-gal-induced oxidative stress in NIH 3T3 cells.

08:00 EDT 7th August 2019 | BioPortfolio

Summary of "Sulfated polysaccharides from Rhodiola sachalinensis reduce d-gal-induced oxidative stress in NIH 3T3 cells."

In this study, three sulfated polysaccharides (S-RSP, S-RSP and S-RSP) from Rhodiola sachalinensis were produced by chlorosulfonic acid-pyridine method. d-gal was used to develop an oxidative stress model in the mouse embryonic fibroblast cell line NIH 3T3. Effects of the three sulfated polysaccharides on d-gal-induced oxidative stress were investigated. The results showed that S-RSP improved the viability of the d-gal-induced oxidative stress in NIH 3T3 cells. The sulfated polysaccharides were found to have a better protective effect against d-gal-induced oxidative stress as compared to the native polysaccharide. Scanning electronmicroscopy also showed a significant change in the surface morphology of sulfated polysaccharides. In addition, the sulfated polysaccharides had noticeable DPPH radical-scavenging activity. In summary, our results demonstrated that d-gal was able to induce oxidative stress in NIH 3T3 cells, and sulfated group might play an important role in resistance to d-gal-induced oxidative damage.

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This article was published in the following journal.

Name: International journal of biological macromolecules
ISSN: 1879-0003
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Medical and Biotech [MESH] Definitions

A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES.

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