Topics

Preparation, preliminary pharmacokinetics and brain tissue distribution of Tanshinone IIA and Tetramethylpyrazine composite nanoemulsions.

08:00 EDT 13th August 2019 | BioPortfolio

Summary of "Preparation, preliminary pharmacokinetics and brain tissue distribution of Tanshinone IIA and Tetramethylpyrazine composite nanoemulsions."

Tanshinone IIA (TSN) is a liposoluble from the Bunge, which promotes blood circulation, decreases inflammation, and has relevance in treating brain-related illnesses. Tetramethylpyrazine (TMP) is important bioactive and has been clinically used in the treatment of nervous and cardiovascular system diseases. TSN and TMP were combined in a composite, oil-in-water nanoemulsions (TSN/TMP O/W NEs) was prepared to prolong and circulation time, and enhance bioavailability of TSN. A formulation was optimized, yielding a 32.5 nm average particle size, an encapsulation efficiency of over 95%, and were spherical in shape as shown by TEM. TSN/TMP O/W NEs were shown to extend the release and availability compared to raw compounds. In pharmacokinetic study, the AUC and t of the TSN/TMP O/W NEs were 481.50 mg/L*min and 346.39 min higher than TSN solution, respectively. Brain tissue concentration of TSN was enhanced with TSN/TMP O/W NEs over raw TSN and even TSN O/W NEs. Therefore, nanoemulstions are an effective carrier to increase encapsulation efficiency of drugs, improve bioavailability and brain penetration for TSN - which is further enhanced by pairing with the co-delivery of TMP, providing a promising drug delivery.

Affiliation

Journal Details

This article was published in the following journal.

Name: Pharmaceutical development and technology
ISSN: 1097-9867
Pages: 1-21

Links

DeepDyve research library

PubMed Articles [20023 Associated PubMed Articles listed on BioPortfolio]

Pharmacokinetics and Tissue Distribution of 3,4-Diaminopyridine in Rats.

Lambert-Eaton myasthenic syndrome (LEMS) is characterized by muscle weakness, amyotrophy, easy fatigability, and depressed tendon reflexes. 3,4-Diaminopyridine (3,4-DAP) is the recommended therapy for...

Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice.

Aegeline is claimed to be a biologically active constituent of . Preclinical studies have reported possible therapeutic potential for aegeline against obesity and diabetes. In recent years, aegeline h...

Determination of D-limonene in mice plasma and tissues by a new GC-MS/MS method: Comparison of the pharmacokinetics, tissue distribution by oral and inhalation administration in mice.

The aim of the present study was to develop a method based on gas chromatography-tandem mass spectrometry (GC-MS/MS) to determine and quantify the D-limonene (DL) in mice plasma and tissue samples. Th...

A novel xanthine oxidase inhibitor WSJ-557 study on pharmacokinetics and tissue distribution in rats by UPLC-MS/MS.

As a novel non-purine xanthine oxidase inhibitor, WSJ-557 is a potential drug for gout. To determine the WSJ-557 concentration in plasma and various tissues of rats, a fast and sensitive method was fi...

A validated UHPLC-MS/MS method for measurement of pharmacokinetics and tissue distribution of trolline in rat.

As a novel alkaloid, trolline is a potential methionine aminopeptidase Ⅱ inhibitor. However, up to now, no informations about the quantification of trolline were available in biosamples. In this stu...

Clinical Trials [15485 Associated Clinical Trials listed on BioPortfolio]

Sodium Tanshinone IIA Sulfonate in Left Ventricular Remodeling Secondary to Acute Myocardial Infarction

Approximately 60 patients with ST-segment elevation myocardial infarction successfully treated with primary percutaneous coronary intervention will be enrolled and randomized to receive t...

Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain...

Brain Tissue Imprint

This exploratory study aims to validate the collection and analysis of brain tissue imprints during the DBS by using a CE marked Medical Device in patients presenting one of the following ...

Evaluation of the Pharmacokinetics of Caspofungin in ICU Patients

Although the pharmacokinetics of Caspofungin has been studied in healthy subjects and patients, only a few studies have been performed in critically-ill patients. In these patients several...

Sex Differences in Gene Expression in Human Adipose Tissue

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand: 1. The mechanisms of ...

Medical and Biotech [MESH] Definitions

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

The probability distribution associated with two mutually exclusive outcomes; used to model cumulative incidence rates and prevalence rates. The Bernoulli distribution is a special case of binomial distribution.

Functions, equipment, and facilities concerned with the preparation and distribution of ready-to-eat food.

Quick Search


DeepDyve research library

Relevant Topics

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Drug Delivery
<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...


Searches Linking to this Article