Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis.

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Summary of "Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis."

The selection of sample times for a pharmacokinetic study is important when trapezoidal integration (e.g. non-compartmental analysis) is used to determine the area under the concentration-time curve (AUC). The aim of this study was to develop an algorithm that determines optimal times that provide the most accurate AUC by minimising trapezoidal integration error.


Journal Details

This article was published in the following journal.

Name: The Journal of pharmacy and pharmacology
ISSN: 2042-7158


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Medical and Biotech [MESH] Definitions

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Method for determining the circulating blood volume by introducing a known quantity of foreign substance into the blood and determining its concentration some minutes later when thorough mixing has occurred. From these two values the blood volume can be calculated by dividing the quantity of injected material by its concentration in the blood at the time of uniform mixing. Generally expressed as cubic centimeters or liters per kilogram of body weight.

The ability to estimate periods of time lapsed or duration of time.

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