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B cell novel protein 1 (BCNP1) has recently been identified as a new B cell receptor (BCR) signaling molecule but its physiological function remains unknown. Here we demonstrate that mice deficient in BCNP1 exhibit impaired B cell maturation and a reduction of B-1a cells. BCNP1-deficient spleen B cells show enhanced survival, proliferation and Ca2+ influx in response to BCR crosslinking as compared with WT spleen B cells. Consistently, mutant B cells show elevated phosphorylation of SYK, B cell linker protein (BLNK) and PLCγ2 upon BCR crosslinking. In vivo, BCNP1-deficient mice exhibit enhanced humoral immune responses to T-independent and -dependent antigens. Moreover, aged mutant mice contain elevated levels of serum IgM and IgG3 antibodies and exhibit polyclonal and monoclonal B cell expansion in lymphoid organs. These results reveal distinct roles for BCNP1 in B cell development, activation and homeostasis.
This article was published in the following journal.
Name: International immunology
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A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.
Techniques for separating distinct populations of cells.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
Developmental events leading to the formation of adult muscular system, which includes differentiation of the various types of muscle cell precursors, migration of myoblasts, activation of myogenesis and development of muscle anchorage.
An SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development.
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