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Distinct roles of BCNP1 in B cell development and activation.

08:00 EDT 15th August 2019 | BioPortfolio

Summary of "Distinct roles of BCNP1 in B cell development and activation."

B cell novel protein 1 (BCNP1) has recently been identified as a new B cell receptor (BCR) signaling molecule but its physiological function remains unknown. Here we demonstrate that mice deficient in BCNP1 exhibit impaired B cell maturation and a reduction of B-1a cells. BCNP1-deficient spleen B cells show enhanced survival, proliferation and Ca2+ influx in response to BCR crosslinking as compared with WT spleen B cells. Consistently, mutant B cells show elevated phosphorylation of SYK, B cell linker protein (BLNK) and PLCγ2 upon BCR crosslinking. In vivo, BCNP1-deficient mice exhibit enhanced humoral immune responses to T-independent and -dependent antigens. Moreover, aged mutant mice contain elevated levels of serum IgM and IgG3 antibodies and exhibit polyclonal and monoclonal B cell expansion in lymphoid organs. These results reveal distinct roles for BCNP1 in B cell development, activation and homeostasis.

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Name: International immunology
ISSN: 1460-2377
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