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History shows that the discovery of, and the resistance to, antibiotics go hand in hand. While knowledge of resistance mechanisms, their impact and distribution is vast, over the years, the topic of antibiotic degradation has often been overlooked and regarded as being discrete from the research on resistance. As a result, understanding of the degradation of antibiotics and the impact of antibiotic degraders on the environment and human health are, for most classes, neither thoroughly documented nor understood. Current information on the biodegradation of antibiotics is described in two review articles. This first part focuses on sulfonamides, trimethoprim, aminoglycosides, amphenicols and tetracyclines. Detailed metabolic and molecular aspects as well as the role of the degraders in natural microbial communities are discussed. An integrated analysis of the accumulated data indicates that appreciation of the interplay between resistance and degradation is quite fragmented, and closing this gap will require novel experimental approaches.
This article was published in the following journal.
Name: New biotechnology
Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degr...
The resistance of bacterial pathogens to antibiotics is one of the most important issues of modern health care. The human microbiota can accumulate resistance determinants and transfer them to pathoge...
The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic producers are an integral part of the growing antibiotic resistance threat. The origins of clinically relevant ant...
Although Enterococci compromise an essential part of normal gut microbiota of both animals and humans, they have emerged as a leading opportunistic pathogen causing infections. The pathogenesis of ent...
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Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU). It will investigate the effects of ...
Antibiotic resistance is a very serious and dangerous situation in modern world. Judicious use of antibiotics is therefore of extreme importance not just in preventing antibiotic resistanc...
Sepsis is a life threatening organ dysfunction caused by infection. Severe sepsis is expected to rise due to resistance to antibiotics. Inappropriate use of antibiotics in the ICU leads to...
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection? Adults with...
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
The ability of fungi to resist or to become tolerant to chemotherapeutic agents, antifungal agents, or antibiotics. This resistance may be acquired through gene mutation.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Substances obtained from various species of microorganisms that are, alone or in combination with other agents, of use in treating various forms of tuberculosis; most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic.