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Psychotropic effects of -theanine and its clinical properties: from the management of anxiety and stress to a potential use in schizophrenia.

08:00 EDT 11th August 2019 | BioPortfolio

Summary of "Psychotropic effects of -theanine and its clinical properties: from the management of anxiety and stress to a potential use in schizophrenia."

Anxiety disorders are highly prevalent in modern societies, and are ranked the sixth most important contributor of non-fatal negative health outcomes. -theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of -theanine for the negative impact of anxiety and psychological stress on health. In this integrative narrative review, we aimed to appraise and further discuss the effects of -theanine administration on anxiety disorders and psychological stress. Published data suggests that -theanine administered at daily doses ranging from 200 to 400 mg for up to 8 weeks are safe and induce anxiolytic and anti-stress effects in acute and chronic conditions. -theanine at doses lower and higher than these may also show promising therapeutic potential; however, a more thorough investigation through randomized double-blind placebo-controlled crossover clinical trials are necessary to elucidate its effects for longer periods, providing further insights for meta-analyses and the development of recommendation guidelines. Additionally, animal studies investigating a higher dosage, its combination with other pharmacological compounds and associated metabolic comorbidities are recommended, as cases of hepatotoxicity associated with the consumption of green tea extract have been reported.

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This article was published in the following journal.

Name: Pharmacological research
ISSN: 1096-1186
Pages: 104395

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