Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: a systematic review.

08:00 EDT 11th August 2019 | BioPortfolio

Summary of "Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: a systematic review."

In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.


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This article was published in the following journal.

Name: Neuroscience and biobehavioral reviews
ISSN: 1873-7528


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Medical and Biotech [MESH] Definitions

Individuals connecting by family, work or other interests. It also includes connectivity facilitated by computer-based communications.

A condition caused by autosomal recessive gene mutations leading to hypogenesis or absence (agenesis) or of CORPUS CALLOSUM, the band of nerve fibers joining the two CEREBRAL HEMISPHERES. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.

Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.

Complete severing of the CORPUS CALLOSUM. In humans it is usually performed to treat medically intractable, multifocal EPILEPSY. EXPERIMENTAL ANIMAL MODELS of split brain preparations are used in research.

Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.

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