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In the absence of the corpus callosum due to either surgical transection or congenital agenesis, the interhemispheric exchange of information is disrupted, as emphasized by several clinical studies. In such cases, a reduction of interhemispheric functional connectivity, that is, an increased independence of the functional signals of the two disconnected hemispheres, is expected to occur. A growing literature has investigated this hypothesis, and a number of studies were able to confirm it. However, this increased independence is not always observed, especially in congenital agenesis, in which the functional signals of the two hemispheres are often found to be characterized by synchronization or correlation. The extent of these counterintuitive findings and possible explanations are discussed. Overall, these findings highlight both methodological and theoretical considerations that emphasize the importance of subcortical structures, the preservation of which may underlie alternative pathways of functional connectivity and interhemispheric communication.
This article was published in the following journal.
Name: Neuroscience and biobehavioral reviews
Individuals with attention-deficit/hyperactivity disorder have disrupted functional connectivity in the default mode and task positive networks. Traditional fMRI analysis techniques that focus on 'sta...
Functional connectivity is widely used to study the coordination of activity between brain regions over time. Functional connectivity in the default mode and task positive networks is particularly imp...
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The purpose of this study is to assess the neurological development at three years of age of children born after prenatal diagnosis of "isolated" agenesis of the corpus callosum.
Individuals connecting by family, work or other interests. It also includes connectivity facilitated by computer-based communications.
A condition caused by autosomal recessive gene mutations leading to hypogenesis or absence (agenesis) or of CORPUS CALLOSUM, the band of nerve fibers joining the two CEREBRAL HEMISPHERES. Clinical features include MENTAL RETARDATION; CRANIOFACIAL ABNORMALITIES; digital malformations, and growth retardation.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
Complete severing of the CORPUS CALLOSUM. In humans it is usually performed to treat medically intractable, multifocal EPILEPSY. EXPERIMENTAL ANIMAL MODELS of split brain preparations are used in research.
Transference of brain tissue, either from a fetus or from a born individual, between individuals of the same species or between individuals of different species.
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...
Congenital conditions are those which are present from birth. They include structural deformities or loss of function in organs such as the <!--LGfEGNT2Lhm-->heart, gut or skeletal system. They can be corrected by <!--LGfEGNT2Lhm-->surgery, m...