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Compromised Mitochondrial Protein Import Acts as a Signal for UPR.

08:00 EDT 13th August 2019 | BioPortfolio

Summary of "Compromised Mitochondrial Protein Import Acts as a Signal for UPR."

The induction of the mitochondrial unfolded protein response (UPR) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C. elegans genome and identified 171 genes that, when knocked down, induce the expression of an hsp-6 HSP70 reporter and encode mitochondrial proteins. These genes represent many, but not all, mitochondrial processes (e.g., mitochondrial calcium homeostasis and mitophagy are not represented). Knockdown of these genes leads to reduced mitochondrial membrane potential and, hence, decreased protein import into mitochondria. In addition, it induces UPR in a manner that is dependent on ATFS-1 but that is not antagonized by the kinase GCN-2. We propose that compromised mitochondrial protein import signals the induction of UPR and that the mitochondrial targeting sequence of ATFS-1 functions as a sensor for this signal.

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Journal Details

This article was published in the following journal.

Name: Cell reports
ISSN: 2211-1247
Pages: 1659-1669.e5

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