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We propose that ramping time cells in the lateral entorhinal cortex can be produced by synaptic adaptation and demonstrate this in an integrate-and-fire attractor network model. We propose that competitive networks in the hippocampal system can convert these entorhinal ramping cells into hippocampal time cells and demonstrate this in a competitive network. We propose that this conversion is necessary to provide orthogonal hippocampal time representations to encode the temporal sequence of events in hippocampal episodic memory, and we support that with analytic arguments. We demonstrate that this processing can produce hippocampal neuronal ensembles that not only show replay of the sequence later on, but can also do this in reverse order in reverse replay. This research addresses a major issue in neuroscience: the mechanisms by which time is encoded in the brain and how the time representations are then useful in the hippocampal memory of events and their order.
This article was published in the following journal.
Name: Cell reports
A key function of the hippocampus and entorhinal cortex is to bridge events that are discontinuous in time, and it has been proposed that medial entorhinal cortex (mEC) supports memory retention by su...
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Increased activity in the hippocampus (i.e. hyperactivity) during a memory task in the magnetic resonance (MR) scanner was found both in healthy elderly participants as well as in patients...
The study aimed to investigate the memory preservation and neurocognitive function protection of hippocampal avoidance whole brain radiotherapy (HA-WBRT) among people who speak Mandarin Ch...
The purpose of this study is to examine how a part of the brain called the hippocampus contributes to memory changes that occur with aging and Alzheimer's disease (AD). Memory problems ar...
Cushing's disease is a state of chronic endogenous glucocorticoid excess. Cushing's disease is responsible for increased morbidity and mortality. Recent studies have pinpointed the frequen...
Type of declarative memory, consisting of personal memory in contrast to general knowledge.
Loss of the ability to form new memories beyond a certain point in time. This condition may be organic or psychogenic in origin. Organically induced anterograde amnesia may follow CRANIOCEREBRAL TRAUMA; SEIZURES; ANOXIA; and other conditions which adversely affect neural structures associated with memory formation (e.g., the HIPPOCAMPUS; FORNIX (BRAIN); MAMMILLARY BODIES; and ANTERIOR THALAMIC NUCLEI). (From Memory 1997 Jan-Mar;5(1-2):49-71)
A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle. The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A neuropsychological test designed to assess different memory functions. It may incorporate an optional cognitive exam (Brief Cognitive Status Exam) that helps to assess memory related cognitive function.
A system of metabolic interactions by products produced in the distal nephron of the KIDNEY. These products include KALLIKREIN; KININS; KININASE I; KININASE II; and ENKEPHALINASE. This system participates in the control of renal functions. It interacts with the RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM to regulate BLOOD PRESSURE, generation of PROSTAGLANDINS, release of VASOPRESSINS, and WATER-ELECTROLYTE BALANCE.