08:00 EDT 14th August 2019 | BioPortfolio


To correlate the size of autonomously functioning thyroid nodules (AFTN) with thyroid function tests. A retrospective analysis of data from patients with a diagnosis of a single AFTN who were seen in a university-based endocrinology clinic between January 1, 2003 and December 31, 2015 was performed. Patients with a nuclear thyroid scan confirming the presence of an AFTN without significant cystic degeneration were included in the study. The volume of the AFTN and the corresponding thyroid function tests were compared in 32 patients who met inclusion criteria. There was no correlation between the volume of the AFTN and thyroid stimulating hormone (TSH) levels (r = 0.044). There was also no volume threshold below which an AFTN was always associated with a TSH within the reference range. The results agree with the findings of other recent studies comparing the volume of AFTNs with TSH levels, suggesting that smaller nodules can still demonstrate subclinical and overt hyperthyroidism and a normal TSH level does not preclude the presence of an AFTN.


Journal Details

This article was published in the following journal.

Name: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
ISSN: 1530-891X


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Medical and Biotech [MESH] Definitions

A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

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The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

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