08:00 EDT 14th August 2019 | BioPortfolio


It is still controversial whether differentiated thyroid carcinoma (DTC) in patients with Graves' disease (GD) can be more aggressive than non-Graves' DTC. We conducted a systematic review and meta-analysis to examine the association between GD and prognosis in patients with DTC. We comprehensively searched the databases of MEDLINE and EMBASE from inception to March 2019. We included published studies that compared the risk of mortality and prognosis between DTC patients with GD and those with non-GD. Data from each study were combined using the random-effects model. Twenty-five studies from February 1988 to May 2018 were included (987 DTC patients with GD and 2,064 non-Graves' DTC patients). The DTC patients with GD had a significantly higher risk of associated multifocality/multicentricity (odds ratio=1.45, 95% confidence interval: 1.04-2.02, I=6.5%, p=0.381) and distant metastasis at the time of cancer diagnosis (odds ratio=2.19, 95% confidence interval: 1.08-4.47, I=0.0%, p=0.497), but this was not associated with DTC-related mortality and recurrence/persistence during follow-up. Our meta-analysis demonstrates a statistically significant increased risk of multifocality/multicentricity and distant metastasis at the time of cancer diagnosis in DTC patients with GD than those without GD.


Journal Details

This article was published in the following journal.

Name: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
ISSN: 1530-891X


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Medical and Biotech [MESH] Definitions

A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).

Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.

An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.

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Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).

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