Visual epidural field potentials possess high functional specificity in single trials.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Visual epidural field potentials possess high functional specificity in single trials."

Recordings of epidural field potentials (EFPs) allow to acquire neuronal activity over a large region of cortical tissue with minimal invasiveness. Because electrodes are placed on top of the dura and do not enter the neuronal tissue, EFPs offer intriguing options for both clinical and basic science research. On the other hand, EFPs represent the integrated activity of larger neuronal populations, possess a higher trial-by-trial variability, and a reduced signal-to-noise ratio due the additional barrier of the dura. It is thus unclear whether and to what extent EFPs have sufficient spatial selectivity to allow for conclusions about the underlying functional cortical architecture, and whether single EFP trials provide enough information on the short time scales relevant for many clinical and basic neuroscience purposes. We here use the high spatial resolution of primary visual cortex to address these issues and investigate the extent to which very short EFP traces allow reliable decoding of spatial information. We briefly presented different visual objects at one out of nine closely adjacent locations and recorded neuronal activity with a high-density, epidural multi-electrode array in three macaque monkeys. Using receiver-operating characteristics to identify most-informative data, machine-learning algorithms provided close-to-perfect classification rates for all 27 stimulus conditions. A binary classifier applying a simple max function on ROC-selected data further showed that single trials might be classified with 100% performance even without advanced offline classifiers. Thus, although highly variable, EFPs constitute an extremely valuable source of information and offer new perspectives for minimally invasive recording of large-scale networks.


Journal Details

This article was published in the following journal.

Name: Journal of neurophysiology
ISSN: 1522-1598


DeepDyve research library

PubMed Articles [29248 Associated PubMed Articles listed on BioPortfolio]

Semi-invasive and non-invasive recording of visual evoked potentials in mice.

Visual evoked potentials (VEPs) are used to assess visual function in preclinical models of neurodegenerative diseases. VEP recording with epidural screw electrodes is a common method to study visual ...

Sparse model-based estimation of functional dependence in high-dimensional field and spike multiscale networks.

Behavior is encoded across multiple scales of brain activity, from binary neuronal spikes to continuous fields including local field potentials (LFP). Multiscale models need to describe both the encod...

Visual vs. computer-based computed tomography analysis for the identification of functional patterns in interstitial lung diseases.

Computer algorithms possess an intrinsic speed, objectivity, reproducibility and scalability unmatched by visual quantitation methods performed by trained readers. The question of how well quantitativ...

High density mapping of aortic cusps improves near field detection of pre-potentials during premature ventricular contractions.

Recognition of pre-potentials during activation mapping of aortic cusp premature ventricular contractions is useful to localize the precise site of origin and is an indicator of successful ablation, b...

Scotopic multifocal visual evoked potentials.

To investigate the scope of scotopic multifocal visual evoked potentials (mfVEP) for the assessment of scotopic visual fields.

Clinical Trials [10889 Associated Clinical Trials listed on BioPortfolio]

Frequency Doubling Technology (FDT) Mobile Visual Field Testing

This is a single center, prospective study to evaluate the efficacy and reproducibility of frequency doubling technology (FDT)-based visual field devices compared to conventional Humphrey ...

How Well Does the Data Obtained From Heidelberg Edge Perimeter Visual Field Compare to Standard Octopus Visual Field

The purpose of this study is to compare standard automated perimetry (SAP) using the Heidelberg Edge Perimeter (HEP) with the Octopus Visual Field (OVF) analyzer and determine test-retest ...

Feasibility of Visual Field Testing With a Virtual Reality Headset

This study aim to determine the feasibility of using a virtual reality (VR) headset (HTC Vive) to test the visual field. The VR headset test will be compared to a conventional visual field...

Visual Restoration for Hemianopia

The purpose of this research is to assess the efficacy of a visual training task on reducing the size of a visual field deficit caused by brain damage in adults, and its ability to improve...

Variability in Perimetry Study

Improved Assessment of Visual Field Change is a trial aimed at investigating mechanisms of visual field testing variability. We have found using larger stimulus size substantially lowers s...

Medical and Biotech [MESH] Definitions

The recorded electrical responses from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Often used synonymously to event-related potentials which are associated with higher level cognitive processes.

Partial or complete loss of vision in one half of the visual field(s) of one or both eyes. Subtypes include altitudinal hemianopsia, characterized by a visual defect above or below the horizontal meridian of the visual field. Homonymous hemianopsia refers to a visual defect that affects both eyes equally, and occurs either to the left or right of the midline of the visual field. Binasal hemianopsia consists of loss of vision in the nasal hemifields of both eyes. Bitemporal hemianopsia is the bilateral loss of vision in the temporal fields. Quadrantanopsia refers to loss of vision in one quarter of the visual field in one or both eyes.

The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.

The injection of autologous blood into the epidural space either as a prophylactic treatment immediately following an epidural puncture or for treatment of headache as a result of an epidural puncture.

Repetitive visual hallucinations experienced mostly by elderly with diminished visual acuity or visual field loss, with awareness of the fictional nature of their hallucinations. It is not associated with delusions and other sensory hallucinations.

Quick Search

DeepDyve research library

Relevant Topic

A diagnostic test is any kind of medical test performed to aid in the diagnosis or detection of disease. For example: to diagnose diseases to measure the progress or recovery from disease to confirm that a person is free from disease Clin...

Searches Linking to this Article