Mechanics of Anteroposterior Axis Formation in Vertebrates.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Mechanics of Anteroposterior Axis Formation in Vertebrates."

The vertebrate anteroposterior axis forms through elongation of multiple tissues during embryogenesis. This process is based on tissue-autonomous mechanisms of force generation and intertissue mechanical coupling whose failure leads to severe developmental anomalies such as body truncation and spina bifida. Similar to other morphogenetic modules, anteroposterior body extension requires both the rearrangement of existing materials-such as cells and extracellular matrix-and the local addition of new materials, i.e., anisotropic growth, through cell proliferation, cell growth, and matrix deposition. Numerous signaling pathways coordinate body axis formation via regulation of cell behavior during tissue rearrangements and/or volumetric growth. From a physical perspective, morphogenesis depends on both cell-generated forces and tissue material properties. As the spatiotemporal variation of these mechanical parameters has recently been explored in the context of vertebrate body elongation, the study of this process is likely to shed light on the cross talk between signaling and mechanics during morphogenesis. Expected final online publication date for the , Volume 35 is October 7, 2019. Please see for revised estimates.


Journal Details

This article was published in the following journal.

Name: Annual review of cell and developmental biology
ISSN: 1530-8995


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