Development and properties of neutralizing monoclonal antibodies for fusion protein of respiratory syncytial virus.

07:00 EST 1st January 2019 | BioPortfolio

Summary of "Development and properties of neutralizing monoclonal antibodies for fusion protein of respiratory syncytial virus."

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections in infants and the elderly. The absence of a wide range of therapeutic drugs and vaccines indicates to the high relevance of the development of new effective drugs for the prevention and treatment of RSV infections.


Journal Details

This article was published in the following journal.

Name: Voprosy virusologii
ISSN: 2411-2097
Pages: 90-96


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Medical and Biotech [MESH] Definitions

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

Antibodies obtained from a single clone of cells grown in mice or rats.

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