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Identification of novel biomarkers of hepatocellular carcinoma by a high definition mass spectrometry; UHPLC-QTOF/MS and DESI-MSI.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Identification of novel biomarkers of hepatocellular carcinoma by a high definition mass spectrometry; UHPLC-QTOF/MS and DESI-MSI."

Hepatocellular carcinoma (HCC) is a highly malignant disease for which the development of prospective or prognostic biomarkers is urgently required. Although metabolomics is widely used for biomarker discovery, there are some bottlenecks regarding the comprehensiveness of detected features, reproducibility of methods, and identification of metabolites. In addition, the information on localization of metabolites in the tumor tissue is needed for functional analysis. Here, we developed a wide-polarity global metabolomics (G-Met) method, identified HCC biomarkers in human liver samples by high-definition mass spectrometry (HDMS) and demonstrated localization in cryosections using desorption electrospray ionization (DESI)-MS imaging (MSI) analysis.

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This article was published in the following journal.

Name: Rapid communications in mass spectrometry : RCM
ISSN: 1097-0231
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