Expression and Clinical Value of Gastrin-Releasing Peptide Precursor in Nephropathy and Chronic Kidney Disease.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Expression and Clinical Value of Gastrin-Releasing Peptide Precursor in Nephropathy and Chronic Kidney Disease."

To explore whether serum proGRP is elevated in nephropathy patients and evaluate the diagnostic value of proGRP in CKD patients.


Journal Details

This article was published in the following journal.

Name: Nephrology (Carlton, Vic.)
ISSN: 1440-1797


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Medical and Biotech [MESH] Definitions

Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS.

L-Tryptophyl-L-methionyl-L-aspartyl-L-phenylalaninamide. The C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.

Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals.

Endocrine cells which secrete GASTRIN, a peptide that induces GASTRIC ACID secretion. They are found predominantly in the GASTRIC GLANDS of PYLORIC ANTRUM in the STOMACH, but can also be found in the DUODENUM, nervous and other tissues.

Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.

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