Praziquantel Ameliorates CCl -induced Liver Fibrosis in Mice by Inhibiting TGF-β/Smad Signalling via Upregulating Smad7 in Hepatic Stellate Cells.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Praziquantel Ameliorates CCl -induced Liver Fibrosis in Mice by Inhibiting TGF-β/Smad Signalling via Upregulating Smad7 in Hepatic Stellate Cells."

Praziquantel (PZQ) is a schistosomicide which has been used for more than 30 years due to its efficiency, safety and mild side effects. Previous studies showed that the prolonged treatment with PZQ could suppress the development of liver fibrosis in schistosomiasis mice. In this study, we investigated the potential mechanisms underlying the antifibrotic role of PZQ.


Journal Details

This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

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