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In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids."

The morbidity and mortality associated with recreational use of synthetic cannabinoid receptor agonists (SCRAs) may reflect strong activation of CB1 receptors and is a major health concern. The properties of SCRA at CB1 are not well defined, so we sought to develop an assay to determine acute CB1 efficacy using receptor depletion with the irreversible CB1 antagonist AM6544, followed by the application of the Black and Leff operational model to calculate efficacy.

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Name: British journal of pharmacology
ISSN: 1476-5381
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An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity.  This can be a drug or biochemical substance or a cell in an organism or organic sample. ...


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