Inhibiting nucleolin reduce inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Inhibiting nucleolin reduce inflammation induced by mitochondrial DNA in cardiomyocytes exposed to hypoxia and reoxygenation."

Cellular debris causes sterile inflammation after myocardial infarction. Mitochondria constitute about 30 percent of the human heart. Mitochondrial DNA (mtDNA) is a damage-associated-molecular-pattern that trigger the immune system and induce injurious sterile inflammation. Little is known about mtDNA's inflammatory signalling pathways in the cardiomyocyte and how mtDNA is internalized to associate with its putative receptor, toll-like receptor 9 (TLR9). We hypothesized that mtDNA can be internalized in cardiomyocytes and induce an inflammatory response.


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This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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