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We describe the establishment of a seronegative occult HBV infection (OBI) in a successfully vaccinated infant who underwent liver transplantation from an antiHBc-positive donor. The use of highly sensitive droplet digital PCR (ddPCR) assays revealed a not negligible and transcriptionally active intrahepatic HBV reservoir (cccDNA, relaxed-circular DNA and pre-genomic
5.6, 2.4 and 1.1 copies/1000 cells, respectively), capable to sustain ongoing viral production and initial liver damage. Next-generation sequencing revealed a peculiar enrichment of HBsAg vaccine-escape mutations that can have played a crucial role in OBI transmission. This clinical case highlights the pathobiological complexity and the diagnostic challenges underlying OBI.
This article was published in the following journal.
Name: The Journal of infectious diseases
A major barrier to curing HIV-1 is the long-lived latent reservoir that supports re-emergence of HIV-1 upon treatment interruption. Targeting this reservoir will require mechanistic insights into the ...
To investigate the frequency of vertically acquired occult hepatitis B virus (HBV) infection (OBI).
Occult hepatitis B virus infection (OBI) frequently occurs in patients with chronic hepatitis C (CHC) infection, but the influence of OBI on CHC outcome is still uncertain. The aim of the present stud...
Although the presence of occult hepatitis C virus (HCV) infection (OCI) is still controversial, however, this infection cannot be ignored. Therefore, the current study aimed at assessing the OCI frequ...
The occult hepatitis B virus infection is a health concern among high-risk groups and immunosuppressed individuals. There is still a paucity of data regarding the OBI among hemophilic patients. With t...
Hepatitis B virus (HBV) infection is a challenging health problem. According to the World Health Organization, an estimated 240 million individuals (3.7%) suffered from chronic HBV infecti...
The main purpose of this study is to unravel the mechanisms by which the "Low Viral Reservoir Treated" patients (LoViReT) maintain extremely low HIV-1 DNA levels despite having initiated c...
The main goal of this study is to identify and characterise the anatomical component of the replication competent HIV-1 (Human Immunodeficiency Virus-1) reservoir. The investigators hypot...
The purpose of this pilot study is to examine the effects of eight 5-day cycles of subcutaneous recombinant interleukin-2 (rIL-2) given every 8 weeks on levels of replication-competent HIV...
This is an open label pilot study to determine whether Mycophenolate mofetil (MMF) given over 22 months meaningfully decreases the size of participants' HIV reservoir. In addition to prim...
An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.
Resin from wood of certain species of GUAIACUM. It is used as clinical reagent for occult blood.
Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood.
The belief in or study of practices and knowledge of magical, mystical, or supernatural powers. ALCHEMY, astrology, and many RELIGIOUS PHILOSOPHIES are based upon occult principles.
Establishment of the age of an individual by examination of their skeletal structure.
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...