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Establishment of a seronegative occult infection with an active HBV reservoir enriched of vaccine escape mutations in a vaccinated infant after liver transplant.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Establishment of a seronegative occult infection with an active HBV reservoir enriched of vaccine escape mutations in a vaccinated infant after liver transplant."

We describe the establishment of a seronegative occult HBV infection (OBI) in a successfully vaccinated infant who underwent liver transplantation from an antiHBc-positive donor. The use of highly sensitive droplet digital PCR (ddPCR) assays revealed a not negligible and transcriptionally active intrahepatic HBV reservoir (cccDNA, relaxed-circular DNA and pre-genomic
RNA:
5.6, 2.4 and 1.1 copies/1000 cells, respectively), capable to sustain ongoing viral production and initial liver damage. Next-generation sequencing revealed a peculiar enrichment of HBsAg vaccine-escape mutations that can have played a crucial role in OBI transmission. This clinical case highlights the pathobiological complexity and the diagnostic challenges underlying OBI.

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This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613
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Medical and Biotech [MESH] Definitions

An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.

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The belief in or study of practices and knowledge of magical, mystical, or supernatural powers. ALCHEMY, astrology, and many RELIGIOUS PHILOSOPHIES are based upon occult principles.

Establishment of the age of an individual by examination of their skeletal structure.

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