Establishment of a seronegative occult infection with an active HBV reservoir enriched of vaccine escape mutations in a vaccinated infant after liver transplant.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Establishment of a seronegative occult infection with an active HBV reservoir enriched of vaccine escape mutations in a vaccinated infant after liver transplant."

We describe the establishment of a seronegative occult HBV infection (OBI) in a successfully vaccinated infant who underwent liver transplantation from an antiHBc-positive donor. The use of highly sensitive droplet digital PCR (ddPCR) assays revealed a not negligible and transcriptionally active intrahepatic HBV reservoir (cccDNA, relaxed-circular DNA and pre-genomic
5.6, 2.4 and 1.1 copies/1000 cells, respectively), capable to sustain ongoing viral production and initial liver damage. Next-generation sequencing revealed a peculiar enrichment of HBsAg vaccine-escape mutations that can have played a crucial role in OBI transmission. This clinical case highlights the pathobiological complexity and the diagnostic challenges underlying OBI.


Journal Details

This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613


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