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Development and Validation of an Improved Pathological Nodal Staging System for Urothelial Carcinoma of the Bladder.

07:00 EST 30th January 2019 | BioPortfolio

Summary of "Development and Validation of an Improved Pathological Nodal Staging System for Urothelial Carcinoma of the Bladder."

Current pathological nodal staging for bladder cancer is based on lymph node (LN) location but not on the number of positive LNs.

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This article was published in the following journal.

Name: European urology oncology
ISSN: 2588-9311
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Medical and Biotech [MESH] Definitions

The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.

Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.

Signaling ligands that act in opposition to NODAL PROTEIN. During vertebrate development they regulate the degree of left-right asymmetry by controlling the spatiotemporal influence of NODAL PROTEIN.

Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.

A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.

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