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Long non-coding RNA HOXA11-AS induces Type I Collagen synthesis to keloid formation via sponging miR-124-3p and activating Smad5 Signaling.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Long non-coding RNA HOXA11-AS induces Type I Collagen synthesis to keloid formation via sponging miR-124-3p and activating Smad5 Signaling."

Keloid, which is characterized as exuberant collagen deposition and invasive growth beyond original wound margins, is the result of abnormal wound healing. A recent microarray analysis revealed HOXA11-AS as a keloid-specific long non-coding RNA. However, little is known on HOXA11-AS during keloid formation.

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This article was published in the following journal.

Name: American journal of physiology. Cell physiology
ISSN: 1522-1563
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Medical and Biotech [MESH] Definitions

A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.

A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.

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A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.

A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.

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