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Twelve sesquiterpene lactones were isolated from the whole plants of . These included eight new compounds, vercinolides A-H (-), along with four known substances (-). The structures of the new compounds were determined by 1D and 2D NMR experiments and mass spectrometric methods. The absolute configurations of compounds - were determined by Mosher experiments and ECD data. Compounds - are the first examples of a new class of sesquiterpene lactones possessing a rare 4α,10α-ether ring and a 2,14-ether ring. Compounds -, , , , and were evaluated for their cytotoxic and anti-inflammatory activities. Compounds and exhibited inhibitory effects against nitric oxide production in lipopolysaccharide-activated RAW 264.7 mouse macrophage cells with IC values of 21 and 23 μM, respectively. Both compounds were inactive for HeLa cells (IC > 10 μM).
This article was published in the following journal.
Name: Journal of natural products
An ultra-high performance liquid chromatography coupled with high-resolution Orbitrap mass spectrometry (UPLC-Orbitrap-MS) method has been used to identify sesquiterpene lactones in the methanolic ext...
Sesquiterpene lactones are naturally occurring compounds that have attracted considerable attention because to their vast array of biological activities. These plant-derived compounds contain the α-m...
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A plant genus of the family MAGNOLIACEAE. The germacranolide sesquiterpene lactones costunolide, parthenolide, and costunolide diepoxide have been isolated from the leaves. Bark contains honokiol and magnolol. Parts are an ingredient of Banxia Houpo Tang.
A plant genus of the family ASTERACEAE that is similar to MATRICARIA but this has tiny chaffy bract scales between each pair of florets. Members contain sesquiterpene lactones. Other plants with similar common names include FERULA; FOENICULUM; MATRICARIA; CHAMAEMELUM and TRIPLEUROSPERMUM.
A plant genus of the family ASTERACEAE. Members contain sesquiterpene lactones.
A plant genus of the family ASTERACEAE. Members contain germacrane and sesquiterpene LACTONES.
A plant genus of the family Jubulaceae, subclass JUNGERMANNIAE. Members contain eudesmane-type sesquiterpene lactones and cause CONTACT DERMATITIS.