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The selective uptake of guests by capsules, cages and containers, and porous solid-state materials such as zeolites and metal-organic frameworks (MOFs) is generally controlled by pore size and by the dimensions and chemical properties of interior host domains. For soluble and solid-state structures, however, few options are available for modifying their outer pores to impart chemoselectivity to the uptake of similarly-sized guests. We now show that by using alkane-coated gold cores as structural building units (SBUs) for the hydrophobic self-assembly of water-soluble suprasphere hosts, ligand exchange can be used to tailor the chemical properties at the pores that provide access to their interiors. For polar polyethylene glycol functionalized ligands, occupancies after equal times increase linearly with the dipole moments of chloro-, nitro- di-chloro and di-nitro (o-, m- and p-) benzene guests. Selectivity is reversed, however, upon incorporation of hydrophobic ligands. The findings demonstrate how self-assembled gold-core SBUs, with replaceable ligands, inherently provide for rationally introducing finely-tuned and quantitatively predictable chemoselectivity to host-guest chemistry in water.
This article was published in the following journal.
Name: Journal of the American Chemical Society
Deracemization is a powerful method by which a racemic mixture can be transformed into an excess of one enantiomer with the aid of chiral auxiliaries, but has been applied only to small chiral molecul...
The cell nucleus is one of the most important organelles as a subcellular drug-delivery target, since modulation of gene replication and expression is effective for treating various diseases. Here, we...
Polycyclic aromatic hydrocarbons as byproducts of carbon-based fuel combustion are an important group of pollutants with wide distribution in the environment. Polycyclic aromatic hydrocarbons are know...
An unreported D,L-tripeptide self-assembled into gels that embedded FeII4L4 metal-organic cages, forming materials that were characterized by TEM, EDX, Raman, rheometry, UV-Vis, NMR and circular dichr...
The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MOPd(PO)] (M = Sn, Pb), have been prepared and structurally characterized in the solid state, solution,...
This research may explain whether a shortage of three special compounds called aromatic amino acids is responsible for the severe illness and high death rate of children with the kwashiork...
This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients w...
Phenylalanine and tyrosine are aromatic amino acids that people need to obtain in their diets. Amino acids are the building blocks for protein, are are therefore required to form tissues i...
This will be a single-arm prospective internally-controlled study. Patients will undergo percutaneous externally-assembled laparoscopic surgery where one or more 3 mm instruments are added...
This clinical trial expansion is to offer patients, who are not enrolled into the Phase I/II trial, a chance of treatment, to extend the experience in this gene therapy, and to increase th...
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.
A dipolar ionic buffer.
Patients' guests and rules for visiting.
The pH in solutions of proteins and related compounds at which the dipolar ions are at a maximum.