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C-N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "C-N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts."

We report diverse C-N cross-coupling reactions of aryl thianthrenium salts that are formed site-selectively by direct C-H functionalization. The scope of N-nucleophiles ranges from primary and secondary alkyl and aryl amines to various N-containing heterocycles, and the overall transformation is applicable to late-stage functionalization of complex, drug-like small molecules.

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Name: Journal of the American Chemical Society
ISSN: 1520-5126
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