Achieving a peak capacity of 1800 using an 8 m long pillar array column.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Achieving a peak capacity of 1800 using an 8 m long pillar array column."

In the present study, the peak capacity potential of ultra-long porous cylindrical pillar array columns is investigated. Coupling 4 columns of 2 m long allows to work near the minimal separation impedance of small molecules under retained conditions at a maximal pressure load of 250 bar. Minimal plate heights of H=5.0 µm, H=6.3 µm and H=7.7 µm were obtained for uracil (unretained), butyrophenone (k=0.85), valerophenone (k=1.94) respectively, corresponding to a number of theoretical plates N=1.6×106, N=1.2×106 and N=1.0×106. The optimal linear velocities were 0.60 mm/s for the retained compounds and 0.74 mm/s for the unretained compound. Based on a mixture of 9 compounds, the peak capacity nc was determined as a function of gradient time (tG). Peak capacities (tG-based) of 1103 and 1815 were obtained when applying 650-min and 2050-min gradients (tG/t0 = 4.5 and 14, respectively, with tG the gradient time and t0 the void time). These values are much higher than earlier reported peak capacity values for small molecules.


Journal Details

This article was published in the following journal.

Name: Analytical chemistry
ISSN: 1520-6882


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