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Achieving a peak capacity of 1800 using an 8 m long pillar array column.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Achieving a peak capacity of 1800 using an 8 m long pillar array column."

In the present study, the peak capacity potential of ultra-long porous cylindrical pillar array columns is investigated. Coupling 4 columns of 2 m long allows to work near the minimal separation impedance of small molecules under retained conditions at a maximal pressure load of 250 bar. Minimal plate heights of H=5.0 µm, H=6.3 µm and H=7.7 µm were obtained for uracil (unretained), butyrophenone (k=0.85), valerophenone (k=1.94) respectively, corresponding to a number of theoretical plates N=1.6×106, N=1.2×106 and N=1.0×106. The optimal linear velocities were 0.60 mm/s for the retained compounds and 0.74 mm/s for the unretained compound. Based on a mixture of 9 compounds, the peak capacity nc was determined as a function of gradient time (tG). Peak capacities (tG-based) of 1103 and 1815 were obtained when applying 650-min and 2050-min gradients (tG/t0 = 4.5 and 14, respectively, with tG the gradient time and t0 the void time). These values are much higher than earlier reported peak capacity values for small molecules.

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Name: Analytical chemistry
ISSN: 1520-6882
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