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Lower Gastrointestinal Conditions: Inflammatory Bowel Disease.

08:00 EDT 1st August 2019 | BioPortfolio

Summary of "Lower Gastrointestinal Conditions: Inflammatory Bowel Disease."

Inflammatory bowel disease (IBD) is a group of diseases that result from an abnormal response to intestinal microbes in a genetically susceptible host. The two major forms are Crohn disease and ulcerative colitis (UC). Crohn disease can involve the entire gastrointestinal tract and the full thickness of the bowel wall. UC is confined to the mucosal layer of the colon. Steroids are used mainly for management of moderate to severely active (ie, acute flares of) IBD. However, steroid use should be limited to the short term because of adverse effects related to long-term usage. Methotrexate is useful for induction and maintenance treatment of Crohn disease. (This is an off-label use of methotrexate.) 5-Aminosalicylates are effective for UC management. Surgery theoretically is curative for UC but is a last resort intervention for Crohn disease. Newer biologic agents are proving useful in IBD management. For patients with these conditions, health maintenance often is the responsibility of the family physician. Patients with IBD should be monitored for osteoporosis, nutritional deficiencies, infections, depression, and cancer.

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This article was published in the following journal.

Name: FP essentials
ISSN: 2159-3000
Pages: 11-19

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Medical and Biotech [MESH] Definitions

Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.

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