Dual Binding Mode of Metallacarborane produces a robust shield on proteins.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Dual Binding Mode of Metallacarborane produces a robust shield on proteins."

An inorganic sandwich molecule, Na[Co(C2B9H11)2], able to produce vesicles through self-assembling, and known to produce strong dihydrogen bond interactions with amine groups shall be capable of interacting with proteins. This dual non-bonding ability of Na[Co(C2B9H11)2], is what makes this molecule unique both to be firmly anchored and capable of extending on a protein surface. To prove so, the widely available Bovine Serum Albumin that has many pendant amino groups in its structure has been taken as the model protein. It is found that around 100 molecules of Na[Co(C2B9H11)2], preserve the native structure of BSA, while endorsing it with a significantly increased stability in front of chemical and thermal induced denaturation due to an efficient encapsulation. The advantages of this encapsulation technique are two, one is its simplicity as it relies in the anchoring capacity of Na[Co(C2B9H11)2] to the surface of the protein through the amine containing residues and two, its self-assembling capacity allowing to spread on the surface. The dense protection shield by the Na[Co(C2B9H11)2] has been demonstrated by the inhibition of BSA pseudo-esterase activity which indicates that the inorganic corset around BSA protects its superficial reactive residues, preventing their acetylation.


Journal Details

This article was published in the following journal.

Name: Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765


DeepDyve research library

PubMed Articles [16541 Associated PubMed Articles listed on BioPortfolio]

Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity.

PUF proteins, named for Drosophila Pumilio (PUM) and Caenorhabditis elegans fem-3-binding factor (FBF), recognize specific sequences in the mRNAs they bind and control. RNA binding by classical PUF pr...

Combinatorial Peptide Ligand Library-based Photoaffinity Probe for the Identification of Phosphotyrosine-Binding Domain Proteins.

Phosphotyrosine (pY) serves as docking site for the recognition proteins containing pY-binding (pYB) modules, such as the SH2 domain, to mediate cell signal transduction. Thus, it is vital to profile ...

Precise Point Positioning Using Dual-Frequency GNSS Observations on Smartphone.

The update of the Android system and the emergence of the dual-frequency GNSS chips enable smartphones to acquire dual-frequency GNSS observations. In this paper, the GPS L1/L5 and Galileo E1/E5a dual...

In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences.

Synthetic proteins with high affinity and selectivity for a protein target can be used as research tools, biomarkers, and pharmacological agents, but few methods exist to design such proteins de novo....

YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization.

As a master regulator of the macroautophagy/autophagy-lysosomal pathway, TFEB (transcription factor EB) plays a prominent role in regulating neurodegenerative diseases and cancer. The transcription ac...

Clinical Trials [3689 Associated Clinical Trials listed on BioPortfolio]

Influence of the Brownie Breast Shield on the Dynamics of Milk Removal

The purpose of this study is to investigate the efficacy of breast drainage of the healthy breast with the new Medela pump set breast shield (Brownie). The objective of the study is to ve...

Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke

Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the co...

Three Way Crossover Closed Loop Study With Xeris Glucagon

Closed-loop systems are an emerging technology that automate hormone delivery. They are quickly paving the way to revolutionize the treatment of type 1 diabetes. Several categories have em...

I-ZIP Ocular Bandage Pivotal Study

To evaluate the safety and performance of the I-ZIP Ocular Bandage in subjects undergoing uneventful unilateral clear corneal phacoemulsification with foldable monofocal intraocular lens (...

Comparison of Peri-implant Tissues Using Socket Shield Technique Versus Xenograft

The aim of this study is to clinically and radiographically evaluate the dimensional changes of soft and hard peri-implant tissues around single immediate post-extraction implants in the e...

Medical and Biotech [MESH] Definitions

A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. They bind to Ras effectors but do not activate them, therefore they may antagonize the effects of RAS PROTEINS. This enzyme was formerly listed as EC

Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.

A subclass of retinol-binding proteins that take part in the intracellular storage and transport of RETINOL. They are both functionally and structurally distinct from PLASMA RETINOL-BINDING PROTEINS.

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.

A family of MONOMERIC GTP-BINDING PROTEINS that are related to RAS PROTEINS.This enzyme was formerly listed as EC

Quick Search

DeepDyve research library

Relevant Topic

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article