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Phenotypic variations of gastric neoplasms in familial adenomatous polyposis are associated with the endoscopic status of atrophic gastritis.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Phenotypic variations of gastric neoplasms in familial adenomatous polyposis are associated with the endoscopic status of atrophic gastritis."

Gastric neoplasms (GNs), including gastric adenoma and carcinoma, are well known as extracolonic manifestations of familial adenomatous polyposis (FAP). We aimed to investigate the clinicopathological features of GNs in FAP patients and to clarify their relationship with the endoscopic status of the background mucosa.

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This article was published in the following journal.

Name: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
ISSN: 1443-1661
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Medical and Biotech [MESH] Definitions

Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.

A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.

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A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.

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