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Novel TFG-RET Fusion in Spindle Cell Tumour with S100 and CD34 Co-Expresssion.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Novel TFG-RET Fusion in Spindle Cell Tumour with S100 and CD34 Co-Expresssion."

The classification of spindle cell tumours with monomorphic morphology and lacking a clear immunophenotype remains challenging. Recurrent fusions involving receptor tyrosine or cytoplasmic kinase genes have been described in various spindle cell tumours . Among these, spindle cell tumours with monomorphic morphology displaying distinct stromal and perivascular hyalinization and co-expressing S100 and CD34 can be grouped into an entity featuring recurrent fusions involving RAF1, BRAF and NTRK1/2 genes . A case with similar morphology showing NCOA4-RET fusion was also described recently . In this report, we describe a case occurring in a child in which a novel gene fusion TFG-RET was identified. This article is protected by copyright. All rights reserved.

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Name: Histopathology
ISSN: 1365-2559
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Medical and Biotech [MESH] Definitions

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