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Enzymatic kinetic resolution of chiral sulfoxides - an enantiocomplementary approach.

08:00 EDT 14th August 2019 | BioPortfolio

Summary of "Enzymatic kinetic resolution of chiral sulfoxides - an enantiocomplementary approach."

A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.

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Name: Chemical communications (Cambridge, England)
ISSN: 1364-548X
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Medical and Biotech [MESH] Definitions

Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.

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